chemReactor BR

Basic glass pilot reactor and pilot plant

Glass reactor: 15, 30, 60 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60 °C (-90°C) to +200 °C
Material: Borosilicate glass 3.3 / glass lined steel / PTFE / PFA / Tantalum

  • Other setups are available.

Performance and reliability are key issues in the explosion proof design of Buchi glass reaction systems. The inert materials allow safe processing in an inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup.
The system consists of:
Reactor, solid jacketed full view glass reactor to easily improve and control chemical reactions by visual observation.
Distillation glass overhead built with buchiflex components (unique flexible ball - socket joints) for multiple, reliable processes under full vacuum.

The BR/GR type chemReactor is a basic pilot reactor system for chemical process development, scale-up, process simulation and kilo-scale cGMP production in batch and semi-batch operation.

We produce complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control as well as integration of auxiliary equipment such as temperature control units, nutsche filters / dryers, scrubbers or mixing vessels.

Package / Options

Standard package

  • Jacketed full glass reactor
  • Multipurpose glass distillation overhead
  • Stainless steel frame, supporting flexible glass superstructure
  • ATEX Zone 1 (0) / CE / cGMP
  • CIP capable
  • FDA conform, highly corrosion resistant
  • Complete documentation

Standard options

  • chemReactor CR type Distillation glass overhead
  • Reactor lift for easy opening (vessel cleaning)
  • Triple wall reactor vessel
  • Sampling device
  • pH monitoring and control
  • Gas introduction (Nitrogen purging and active gas)
  • Vacuum / exhaust piping
  • Additional feeders / receivers
  • Solid feeding
  • IQ / OQ / PQ

Reactor vessel

  • Jacketed glass reactor 15, 30, 60 liter
  • Baffle with Pt100 temperature sensor
  • Flush mounted drain valve (zero dead volume)

Glass dome / Glass lined cover plate

  • Glass cover dome (15, 30, 60 liter)
  • Glass lined steel cover (60 liter)
  • Fast-action closure for addition of solids
  • 8 connection nozzles

ATEX stirrer drive

Distillation glass overhead

  • Feed vessel for liquid addition
  • Distillation column / vapor duct with pressure gauge and bursting disc
  • Spiral condenser with vacuum / exhaust connection
  • Receiver vessel for collection of distillate
  • Self-draining «buchiflex» glass piping
  • for GR type glass-overhead: see chemReactor CR

Typical application

  • Chemical synthesis  
  • Extraction / evaporation  
  • Purification / crystallization  
  • Separation  
  • API manufacturing  
  • Peptide production 
  • Process development 
  • Scale-up 
  • Cryogenic reactions 
  • Small scale production 
  • Pilot plant / kilo lab 
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